PUBLICATIONS

2019

  • Zhang S, Scott E, Singh J, Chen Y, Zhang Y, Elsayed N, Chamberlain MD, Shakiba N, Adams K, Yu S, Morshead CM, Zandstra PW, Wheeler AR.  (2019) The optoelectronic microrobot: A versatile toolbox for micromanipulation. PNAS. July 9. [PUBMED]
  • Morrison TJ, Sefton E, Marquez-Chin M, Popovic MR, Morshead CM, Naguib HE. (2019) A 3D-printed device for low-cost stimulation in mice. Frontiers in Neuroscience. doi:10.3389/fnins.2019.00784.  [PUBMED]
  • Alfhors J-E, Azimi A, El-Ayoubi R, vonderwalde I, Velumian A, Boscher C, Thomson A, Abraham S, Mani S, Mihai O, Samoilova M, Khazaei M, Fehlings MG, Morshead CM. (2019) Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells.  Stem Cell Research and Therapy. 10(1):166. [PUBMED]
  • Payne S, Tuladhar A, Obermeyer JM, Varga BV, Morshead CM, Nagy A, Shoichet MS.  (2019) Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain. Biomaterials, 192:309-322. [PUBMED]
  • Coles B, Brokhman I, Razavi R, Babona-Pilipos R, Morshead CM, Sibley E, Chen C, van der Kooy D. (2019) Dual embryonic origin of the mammalian enteric nervous system. Developmental Biology, 445:256-270. [PUBMED]
  • Obermeyer JM, Tuladhar A, Payne S, Ho E, Morshead CM, Shoichet MS. (2019) Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioural Recovery and Tissue Repair in Stroke Injured Rats. Tissue Engineering Part A, Feb. 27, DOI:10.1089/ten.TEA.2018.0215. [PUBMED]
  • Vonderwalde I, Azimi A, Rolvink G, Ahlfors J-E, Shoichet MS,  Morshead CM.  Transplantation of Human Directly Reprogrammed Neural Precursor Cells Following Stroke Promotes Synaptogenesis and Functional Recovery.  Translational Stroke Research. Feb 12. doi: 10.1007/s12975-019-0691-x. [PUBMED]

2018

  • Nusrat L, Livingston-Thomas J, Raguthevan V, Adams K, vonderwalde I, Corbett D, Morshead CM. (2018) Cyclosporin A mediated activation of endogenous neural precursor cells promotes cognitive recovery in a mouse model of stroke.  Frontiers Neurosci, 10:93-99. [PUBMED]
  • Babona-Popovic R, Liu N, Oh-Pritchard A, Mok A, Badawi D, Popovic M, Morshead CM. (2018) Calcium influx differentially regulates migration velocity and directness in response to electric field application. Experimental Cell Research, 368(2):202-214 [PUBMED]
  • Lakshman N, Xu W, Morshead CM. (2018) A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury.  J Vis Exp. 13:(139). [PUBMED]
  • Adams K, Morshead CM. (2018) Neural stem cell heterogeneity in the mammalian forebrain.  Prog Neurobiol, 170: 2-36. [PUBMED]
  • Iwasa S, Popovich MR, Morshead CM. (2018)  Skin-derived precursor cells undergo substrate dependent galvanotaxis that can be modified by neighbouring cells.  Stem Cell Research, 31:95-101. [PUBMED]

2017

  • Xu W, Lakshman N, Morshead CM. (2017) Building a central nervous system:  the neural stem cell lineage revealed.  Neurogenesis, 4(1), e1300037. [PUBMED]
  • Iwasa S, Babona-Popovic R, Morshead CM. (2017) Environmental factors influencing stem cell migration:  an “electric field”.  Stem Cells International, 2017:4276927. [PUBMED]
  • Payne S, Anandakurmaran PN, Varga BV, Morshead CM, Nagy A, Shoichet MS. (2017) In vitro maturation of human iPS-derived neuroepithelial cells influences transplant survival in the stroke-injured rat brain.  Tissue Engineering, Part A, 24(3-4):351-360. [PUBMED]
  • Reeve RL, Yammine S, Morshead CM, van der Kooy D.  (2017) Quiescent Oct4+ neural stem cells (NSCs) repopulate ablated GFAP+ NSCs in the adult mouse brain. Stem Cells, 35(9):2071-2082. [PUBMED]
  • Ruddy R, Morshead CM. (2017) Home Sweet Home: The neural stem cell niche throughout development and after injury. Cell and Tissue Research, 371(1):125-141. [PUBMED]
  • Wu M, Guan J, Li C, Gunter S, Nusrat L, Ng S, Dhand K, Morshead CM, Kim A, Das S. (2017) Aberrantly activated Cox-2 and Wnt signaling interact to maintain glioma stem cells.  Oncotarget 8 (47): 82217- 82230. [PUBMED]

2016

  • Xu W, Lakshman N, Morshead CM. (2016) Stem cells in the adult CNS revealed:  Examining their regulation by myelin basic protein.  Neural Regeneration Research, 11(12):1916-1917. [PUBMED]
  • Faiz M, Nagy A, Morshead CM. (2016) Response to: Where do you come from and what are you going to become, reactive astrocyte? Stem Cell Investig, 3:32. [PUBMED]
  • Xu W, Huang M, Gappasov A, Azimi A, Sachewsky N, Morshead CM. (2016) Myelin basic protein regulates primitive and definitive neural stem cell proliferation from the adult spinal cord.  Stem Cells, 35(2): 485-496. [PUBMED]
  • Schuch CP, Jeffers MS, Antonescu S, Nguemeni C, Gomez-Smith M, Pereira LO, Morshead CM, Corbett D. (2016) Enriched rehabilitation promotes motor recovery in rats exposed to neonatal hypoxia-ischemia.  Behavioural Brain Research, 304:42-50. [PUBMED]
  • Führmann T, Tam RY, Ballarin B, Coles  B, Donaghue E, van der Kooy D, Nagy A, Tator CH, Morshead CM, Shoichet MS. (2016)  Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates long term teratoma formation after spinal cord injury by inducing differentiation.  Biomaterials, 83: 23-36. [PUBMED]
  • Chow A and Morshead CM. (2016) Cyclosporin A promotes neural precursor cell survival and enhances hippocampal neurogenesis. Stem Cell Research 16 (2016) 79–87.  [PUBMED]

2015

  • Livingston-Thomas J, Jeffers MS, Nguemeni C, Shoichet MS, Morshead CM, Corbett D. (2015). Assessing cognitive function following medial prefrontal stroke in the rat. Behav Brain Res. 294:102-10. [PUBMED]
  • Taludar A, Morshead CM, Shoichet MS.  (2015) Circumventing the Blood-Brain barrier:  Injectable hyaluronan-based hydrogel delivery of Cyclosporin A promotes tissue repair in the stroke injured rat brain.  J Control Rel, 215: 1-11. [PUBMED]
  • Faiz M, Sachewsky N, Gascon S, Bang KW, Nagy A*, Morshead CM*.   (2015) Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke.  Cell Stem Cell. 17(5):624-634 *co-senior and corresponding authors [PUBMED]
  • Dadwal P, Mahmud N, Sinai L, Azimi A, Fatt M, Wondisford F, Miller F, Morshead CM.  (2015) Activating endogenous neural precursor cells using metformin leads to neural repair and functional recovery in a model of childhood brain injury. Stem Cell Reports 5(2), 166–173 [PUBMED]
  • Ballios BG, Cooke MJ, Clarke L, Coles BLK, Morshead CM, van der Kooy D, Shoichet MS. (2015) A hyaluronan based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation.  Stem Cell Reports 4: 1031-1045. [PUBMED]
  • Babona-Piliops R, Pritchard-Oh A, Popovic MR, Morshead CM. (2015) Biphasic monopolar electrical stimulation induces rapid and directed electrotaxis in adult subependymal neural precursors.  Stem Cell Research and Therapy,  6:67 [PUBMED]

2014

  • Sachewsky N, Azimi A, Morshead CM. (2014) Pro-survival factors derived from the embryonic brain promote adult neural stem cell survival. Stem Cells Dev. 23(20): 2469-2481.
  • Sachewsky N, Xu W, Leeder R, Rose KL, Yu F, van der Kooy D, Morshead CM. (2014) Primitive neural stem cells in the adult brain give rise to GFAP-expressing neural stem cells. Stem Cell Reports, 2(6): 810-824.
  • Jeffers M, Hoyles A, Morshead CM, Corbett D (2014) Epidermal growth factor and erythropoietin infusion accelerates functional recovery in combination with rehabilitation. Stroke, 45(6): 1856-8.
  • Piccin D, Tufford A, Morshead CM. (2014) Senescent neural stem cells in the aged brain respond to signals from the young adult brain. Neurobiology of Aging, 35(7):1669-79.

2013

  • Gallagher D, Norman AA, Gauthier-Fisher A, Fujitani M, Cancino GI, Sachewsky N, Vessey JP Woltjen L, Morshead CM, Kaplan DR, Miller FD. (2013) Acutely increased maternal IL-6 mediates long-lasting changes in neural stem cell pools and adult neurogenesis. Cell Stem Cell,13(5):564-76.
  • Wang Y, Cooke MJ, Sachewsky N, Morshead CM, Shoichet MS (2013) Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. J Control Rel, 172(1):1-11
  • Yu F, Li Y, Morshead CM (2013) Induced pluripotent stem cells for the treatment of stroke: Potential promise and pitfalls. Curr Stem Cell Res Ther, 8(5):407-14.
  • Chaudhuri J, Tarulli E, Gretka V, Hoyles A, Morshead CM, Stanisz GJ.(2013) Effectiveness of MPIOs as markers for detection of migration of Bone Marrow Derived Mesenchymal Stromal Cells in a Stroke Model. J Magn Reson Imaging. 2013 Jun;37(6):1409-18.
  • Caicco MJ, Cooke MJ, Wang Y, Tuladhar A, Morshead CM, Shoichet MS (2013) A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke. J Contr Release, 166(3):197-202

2012

  • Piccin D, Yu F, Morshead CM (2012) Notch signaling imparts and preserves adult neural stem cell characteristics in vitro and in vivo. Stem Cells Dev. 2013 May 15;22(10):1541-50.
  • Dibajnia P, Morshead CM. (2012) Role of neural precursor cells in promoting repair following stroke. I Acta Pharmacol Sin. 2012 Oct 15. doi: 10.1038/aps.2012.107.
  • Babona-Pilipos R, Popovic MR, Morshead CM. (2012) A galvanotaxis assay for analysis of neural precursor migration kinetics in an externally applied direct current electric field. JoVE, J Vis Exp. 2012 Oct 13;(68). doi:pii: 4193. 10.3791/4193.
  • Wang Y, Cooke MJ, Morshead CM, Shoichet MS (2012) Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury. Biomaterials 33(9)2681-2692.
  • Guo N, Zahir T, Mothe A, Morshead CM, Shoichet MS, Katayama Y, Tator CH (2012) The effect of growth factors and soluble Nogo66 receptor protein on transplanted neural stem/progenitor survival and axonal regeneration after complete transection of rat spinal cord. Cell Transplantation, 2012; 21(6):1177-97 .

2011

  • Babona-Pilipos R, Droujiine I, Popovic MR, Morshead CM (2011) Neural precursor cells undergo rapid and directed migration in response to physiologically relevant direct current electric fields. PLoS One, Aug 2011, 6(8) e23808.
  • Wylie R, Ahsan S, Maxwell K, Morshead CM, Shoichet MS (2011) Three-dimensional, spatially controlled simultaneous patterning of multiple growth factors in hydrogels. Nat Materials, 10:799-806.
  • Cooke MJ, Wang Y, Morshead CM, Shoichet MS (2011) Controlled cortical delivery of epidermal growth factor stimulates endogenous neural stem cell proliferation in the stroke-injured brain. Biomaterials, 32(24):5688-97.
  • Piccin D, Morshead CM (2011) Wnt signaling regulates symmetry of division in adult neural stem cells. Stem Cells, Dec 29 [Epub ahead of print] 29:528-38.
  • Wang Y, Cooke MJ, Lapitsky Y, Wylie RG, Sachewsky N, Corbett DC, Morshead CM, Shoichet MS (2011) Transport of epidermal growth factor in the stroke-injured brain. J Contr Release, 149(3):225-235.
  • Yu F, Morshead CM (2011) Adult stem cells and bioengineering strategies for the treatment of cerebral ischemic stroke. Curr Stem Cell Res Ther, Apr 11 [Epub ahead of print].
  • Erlandsson A, Lin A, Fenggang Y, Morshead CM (2011) Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury, Exp Neurol, Jul;230(1):48-57

2010

  • Nomura H, Kim H, Mothe A, Zahir T, Kulbatski I, Morshead CM, Shoichet MS, Tator CH (2010) Endogenous radial glial cells support regenerating axons after spinal cord transection. Neuroreport, 21:  871-6.
  • Hunt J, Morshead CM (2010) Cyclosporin A enhances cell survival in neural precursor populations in the adult central nervous system. Mol Cell Pharmacol, 2(3):80-88.
  • Erlandsson A, Lin A, Fenggang Y, Morshead CM (2010) Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury, Exp Neurol, May 31 [Epub ahead of print] doi:10.1016/j.expneurol.2010.05.018
  • Piccin D, Morshead CM (2010) Potential and pitfalls of stem cell therapy in old age, Dis Model Mech, 3:421-425.
  • Scanga V, Goraltchuk A, Nussbai N, Shoichet MS, Morshead CM (2010) Biomaterials for Neural Tissue Engineering: Chitosan supports the survival, migration and differentiation of adult-derived neural stem and progenitor cells. Can J Chem, 88:277-287.
  • Hunt J, Cheng A, Hoyles A, Jervis E, Morshead CM (2010) Cyclosporin A has direct effects on adult neural precursor cells. J. Neurosci, 30:2888-2896. (with commentary in SciBX The Science Business exchange).

2009

  • Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead CM (2009). Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue. Stem Cells Dev, 18:1533-42.

2008

  • Tropepe V, Cheng V, Alton K, Morshead CM (2008). Embryonic mesoderm derived stem cells with neurogenic potential can be isolated from somites and heart, Stem Cells, 18:1533-42.
  • Coles-Takabe BL, Brain I, Purpura KA, Karpowicz P, Zandstra PW, Morshead CM, van der Kooy D (2008) Don’t Look: Growing clonal versus non-clonal neural stem cell colonies. Stem Cells, 26(11):2938-44.
  • Nomura H, Baladie B, Katayama Y, Morshead CM, Shoichet MS, Tator CH. (2008) Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury. Neurosurgery. 2008 Jul;63(1):127-41.
  • Nomura H, Zahir T, Kim H, Katayama Y, Kulbatski I, Morshead CM, Shoichet MS, Tator C (2008) Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection. Tissue Eng. Part A. 14:649-65.
  • Zahir T, Nomura H, XiaoDong G, Kim H, Tator C, Morshead CM, Shoichet MS (2008) Bioengineering neural stem/progenitor cell-coated tubes for spinal cord injury repair. Cell Transplant, 17(3):245-54.

2007

  • Eftekharpour E, Karimi-Abdolrezaee S, Cheng V, Wang J, El-Beheiry H, Morshead CM, Fehlings MG (2007) Myelination of congenitally dysmyelinated spinal cord axons by adult neural precursor cells results in formation of nodes of Ranvier and improved axonal conduction. J. Neurosci, 27(13):3416-28.
  • Kolb B*, Morshead CM*, Gonzalez C, Kim M, Gregg C, Shingo T, Weiss S (2007) Growth factor-stimulated generation of new cortical tissue and functional recovery after Ischemic damage to the motor cortex of rats. J Cereb Blood Flow and Metab, 27:983-987. *contributed equally to the work.

2006

  • Willaime-Morawek S, Seaberg RM, Batista C, Labbe E, Attisano L, Gorski JA, Jones KR, Kam A, Morshead CM, van der Kooy D (2006) Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. J Cell Biology, 175:159-168.
  • Ramunas J, Illman M, Kam A, Farn K, Kelly L, Morshead CM, Jervis EJ (2006) Identification of a behavioral phenotype in neural stem cell cultures: Lineage informatics of undifferentiated neurosphere-derived cells. Cytometry A 69:1202-1211.
  • Erlandsson A, Morshead CM (2006) Exploiting the properties of adult stem cells for the treatment of disease. Curr Opin Molecular Therapeutics 8: 331-337.
  • Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Morshead CM, Fehlings MG (2006) Delayed transplantation of adult neural stem cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci 26(13): 3377-89.
  • Goraltchouk A, Scanga V, Morshead CM, Shoichet MS (2006) Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release. J Con Release 110: 400-407.

2005

  • Karpowicz P, Morshead CM, Kam A, Jervis EJ, Ramunas J, Cheng V, van der Kooy D (2005) Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 170: 721-732.

2004

  • Morshead CM (2004) Neural stem cells in vivo: Solving the identity crisis. Developmental Neurosci 26: 93-100.
  • Zhang R, Zhang Z, Wang L, Wang Y, Gousev A, Zhang L, Ho KL, Morshead C, Chopp M (2004) Activated neural stem cells contribute to stroke induced neurogenesis and neuroblast migration toward the infarct boundary in rats. J Cerebral Bl Flow and Metab. 24:441-448.
  • Morshead CM, van der Kooy D (2004) Disguising adult neural stem cells. Curr Opin Neurobiol 14: 125-131.

2003

  • Kim M, Morshead CM (2003) Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis. J Neurosci 23: 10703-10709.
  • Morshead CM, Garcia AD, Sofroniew MV, van der Kooy D (2003) The ablation of GFAP positive cells from the adult CNS results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci 18: 76-84.

2002

  • Morshead CM, Benveniste P, van der Kooy D, Iscove, NN (2002) Hematopoietic competence is a rare property of neural stem cells and may depend on cell transformation and genetic mutation. Nature Medicine, 8(2): 268-273 (including News and Views commentary).

2001

  • Morshead CM, van der Kooy D (2001) A new spin on neural stem cells? Curr Opin Neurobiol 11: 59-66.

2000

  • Morshead CM, van der Kooy D (2000) A cell survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain. J Neurobiol 42:338-346.

1999

  • Craig CG, D’Sa R, Morshead CM, Roach A, van der Kooy D (1999) Migrational analysis of the constitutively proliferating subependymal cells in the adult forebrain. Neurosci 93(3): 1197-1206.
  • Chiasson BJ, Tropepe V, Morshead CM, van der Kooy D (1999) Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics. J Neurosci 19:4462-4471.

1998

  • Morshead CM, Craig CG, van der Kooy D (1998) In vivo clonal analysis of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development 125: 2251-2261.

1997

  • Tropepe V, Craig CG, Morshead CM, van der Kooy D (1997) Transforming growth factor alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 17(20): 7850-7859.

1996

  • Weiss S, Reynolds BA, Vescovi AL, Morshead C, Craig CG, van der Kooy D (1996) Is there a neural stem cell in the mammalian forebrain? Trends Neurosci 19: 387-393.
  • Craig CG, Tropepe V, Morshead CM, Reynolds BA, Weiss S, van der Kooy D (1996) In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neurosci 16(8): 2649-2658.

1994

  • Morshead CM, Reynolds BA, Craig CG, McBurney MW, Staines WA, Morassutti D, Weiss S, van der Kooy D (1994) Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells. Neuron 13(5): 1071-1082.
  • Wen JYM, Morshead CM and van der Kooy D (1994) Glial proliferation after axotomy is induced by a mitogenic factor released from injured neurons. J Cell Biol 124: 1005-1015.

1992

  • Morshead CM, van der Kooy D (1992) Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain. J Neurosci 12(1): 249-256.

1991

  • Watson CP, Deck JH, Morshead C, van der Kooy D, Evans RJ. (1991) Post-herpetic neuralgia: further post-mortem studies of cases with and without pain. Pain 44:105-17.

1990

  • Morshead CM, van der Kooy D (1990) Separate blood and brain origins of proliferating cells during gliosis in adult brains. Brain Research 535: 237-244.

1988

  • Watson CPN, Morshead CM, van der Kooy D, Evans RJ (1988) Postherpetic Neuralgia: A postmortem analysis. Pain 34: 129-138.

Book chapters

  • Faiz M, Morshead CM. (2017) “Stem Cells to Function” in The neurobiology of brain and behavioural development.  Editors:  R Gibb and B Kolb, Elsevier, 99-132.
  • Corbett D, Morshead CM and Shoichet M. (2012) Efficacy of Transplant and Endogenous Precursor and Stem Cell Interventions on Stroke Recovery: A Critical Assessment of Cell-Based Therapies in Stroke,
    Editors: Jukka Jolkkonen and Piotr Walczak, Springer, 2012.
  • Sachewsky N, Morshead CM. (2008) “Adult stem cells and their role in endogenous tissue repair” in Emerging Technology Platforms for Stem Cells, Lakshmipathy U, Chesnut J, Thyagarajan B (co-Eds). Hoboken, New Jersey: John Wiley & Sons. 89-110.